Li-Shu Wang, PhD

Li-Shu Wang, PhD2017 Presentation Title – The Axis of Gut Bacteria-Metabolites-Their Receptors in Colon Carcinogenesis

Dr. Wang is an Associate Professor of Medicine, Medical College of Wisconsin. Dr. Wang’s research interests are in the prevention of cancers using nature products and their active metabolites. She has experience in evaluating the effects of chemopreventive agents, including black raspberries, on gene expression in vitro (in mammary and colon cell culture systems) and in vivo (in the rat esophagus, colon cancer and pancreatic cancer).

Using bio-directed fractionation, she showed that the anthocyanins in black raspberries are important for their chemopreventive effects and she provided evidence that the ellagitannins may be less important. Recently, she has evidence that berries cause demethylation of tumor suppressor genes in rodent and human colon leading to their enhanced expression in two human clinical trials. The protective effects of berries against human and mouse colorectal cancers are associated, at least in part, with their hypomethylation activities. Loss of responses to berry treatment in humans may be due to decreased sensitivity to berry-induced DNA demethylation. Dr. Wang’s recent findings suggest that berries produced beneficial effects against colonic adenoma development in a mouse colon cancer model and modulated multiple metabolic pathways. Similarly, black raspberry intervention induced significant metabolic changes and affected energy generating pathways in human colon cancer patients.