Susan R. Mallery, DDS, PhD is a professor in the Division of Oral Maxillofacial Surgery, Pathology & Anesthesiology at the Ohio State University College of Dentistry. After obtaining her dental degree, Dr. Mallery practiced general dentistry in addition to pursuing a NIH research fellowship at Georgetown University. She then returned to Ohio State to obtain specialty and graduate training, which was funded by a NIH Individual Dentist Scientist Award. After obtaining her PhD in Experimental Pathology and Board Certification in Oral Pathology, Dr. Mallery joined the Ohio State Dental Faculty. Her faculty position entails participation in an oral pathology clinical practice, didactic and clinical teaching to dental students and residents, and research. Dr. Mallery also participates in research-relevant service including participation as a standing member of Chemical Pathology and Cancer Etiology study sections, and current service as a permanent member of the Chemo Dietary Prevention NIH study section.
Dr. Mallery’s research interests include evaluation of the contributions of oxidative and nitrosative stress in cancer initiation and promotion, study of AIDS-related Kaposi’s sarcoma as a model of pathological angiogenesis, evaluation of local delivery formulations, and chemoprevention using both in vitro and in vivo models. Her current focus lies with the use of natural products, including black raspberries, as chemopreventive agents to prevent progression of premalignant oral epithelial lesions to oral cancer. She is also investigating use of locally injectable polymer vehicles as secondary chemopreventive agents to prevent local recurrence of excised head and neck cancer.
Ongoing berry-relevant laboratory studies in the Mallery lab include evaluation of the effects of bioactivating metabolic and phase II enzymes on the chemopreventive effects of black raspberry anthocyanins. Dr. Mallery also serves as the PI on a NCI funded multicenter, placebo-controlled clinical trial to evaluate the chemopreventive efficacy of a bioadhesive black raspberry gel on lesions of oral epithelial dysplasia.