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Gastroenterology. 1990 Jan; 85(1):248-55. 2010 Jan; 30(1):31-41. 1999 Nov; 20(11):2095-100. J Mol Med (Berl). PLoS One. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Metab. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. PLoS One. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Mol Cell Biol. 1998 Sep; 13(S1):S39-S50. New Developments on the Treatment of Liver Fibrosis. J Exp Med. Hepatology. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. 2017 Aug; 40(2):454-464. He will assume his new role effective September 14. 1998 Jul; 43(7):1454-64. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. Aliment Pharmacol Ther. Clin Gastroenterol Hepatol. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. 2017 01 03; 127(1):55-64. Hepatology. Akt activation protects rat liver from ischemia/reperfusion injury. Cell Mol Gastroenterol Hepatol. J Biol Chem. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Hepatol Commun. Hepatology. 2004 Jun; 135(6):619-28. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Am J Physiol Gastrointest Liver Physiol. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Awareness, treatment, and control of vascular risk factors among stroke survivors. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Gastroenterology. 1997 May; 272(5 Pt 1):G943-53. 1991 Mar; 5(3):275-81. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. 1990 Jun; 11(6):909-15. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. 2020 Nov 03; 32(5):901. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Clin Gastroenterol Hepatol. Arch Biochem Biophys. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. J Clin Invest. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Cell Host Microbe. 1998 May; 27(5):1285-95. 2000; 35 Suppl 12:80-3. 2021 08 01; 321(2):H435-H445. Hepatology. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? People who share similar concepts with this person. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Cell Mol Gastroenterol Hepatol. Arch Clin Biomed Res. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Nat Commun. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. J Gastroenterol Hepatol. 2021; 16(12):e0260721. Clinical syndromes of alcoholic liver disease. 2008 Nov; 48(5):1420-9. Gastroenterol Res Pract. J Theor Biol. 2006 May; 130(6):1562. J Lab Clin Med. 2011 Jan; 53(1):96-105. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. 2016; 34(5):589-96. 1994 Jun 21; 91(13):6030-4. Gastroenterology. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. 1998 08; 275(2):G269-78. J Biol Chem. 2004 Feb; 24(4):1758-68. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Semin Liver Dis. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Cell Death Differ. 1998 Nov; 18(11):6353-64. Biochim Biophys Acta. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. 1989 May; 9(5):2224-7. Proc Natl Acad Sci U S A. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. 1985 Apr; 5(4):684-91. Stroke. 2000 Jul; 33(1):49-58. J Biol Chem. 2005 Jul 29; 280(30):27879-87. J Clin Invest. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. New functions for the aryl hydrocarbon receptor. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Transient induction of c-jun during hepatic regeneration. Kenji Fujiwara, MD, PhD. 2002 Sep; 123(3):877-8. Gastroenterology. Carcinogenesis. 1999 Oct 22; 274(43):30919-26. 2001 Jul 01; 167(1):173-80. 1988 Jan-Feb; 8(1):176-82. Gastroenterology. 2011 Oct; 89(10):997-1013. Hepatology. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. J Gastroenterol Hepatol. 1991 Jun; 87(6):2230-5. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. 2012 Sep; 56(3):922-32. Am J Hum Genet. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. J Stroke Cerebrovasc Dis. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. 2020 05; 158(6):1728-1744.e14. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Molecular mechanisms of alcohol-induced hepatic fibrosis. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. This graph shows the total number of publications by year. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Analysis of the human ferrochelatase promoter in transgenic mice. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. J Biol Chem. Hepatology. 2004 Dec; 127(6):1659. 2003 Apr; 27(4):726-31. Infect Immun. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Hepatology. Front Biosci. Cell Metab. 2007 Apr; 132(4):1434-46. 2005 Sep-Oct; 7(9-10):1346-55. Am J Respir Cell Mol Biol. 2015 Apr 06; 212(4):469-80. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Clin Gastroenterol Hepatol. Compr Ther. J Immunol. 2014 Jun 10; 20(17):2854-72. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. 2005 Sep; 230(8):573-86. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. Yale J Biol Med. 2008 Dec; 48(6):2016-26. 1990 Apr; 7(2):105-15. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. Aliment Pharmacol Ther. J Immunol. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. 2011 Jul; 41(7):683-6. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. 2017 Feb 01; 312(2):C131-C143. 2007 May; 132(5):1937-46. Is it the end of the line for the EMT? 1990 Dec; 9(10):777-81. J Clin Invest. 2005; 23(3-4):255-63. Nat Med. 2012 Nov; 143(5):1330-1340.e1. J Gastroenterol Hepatol. 2004 Oct; 127(4):1260-2. Am J Physiol Cell Physiol. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. 2016 05; 139(Pt 5):e28. Mol Metab. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. Cancer Res. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. 2008 Nov; 135(5):1729-38. Immunol Res. JCI Insight. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. 1988 Apr 25; 263(12):5841-5. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Hepatology. J Biol Chem. Hepatology. Techniques to measure nucleic acid-protein binding and specificity. DNA. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. 2004 May 28; 279(22):23822-9. 2012; 5(Suppl 1):S17. 2014 Jul; 124(7):2921-34. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. 2014 Oct; 27(5):413-25. Fibrogenesis of parenchymal organs. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. J Hepatol. 2000 Feb; 88(2):142-9. Hepatology. 2003 Jan 01; 8:d69-77. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Fibrogenesis Tissue Repair. Am J Pathol. Hepatology. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. J Hepatol. Hepatology. 2015 Dec; 149(7):1784-93. 2006 May; 130(6):1564-72. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Am J Physiol Heart Circ Physiol. Alcohol Clin Exp Res. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. J Cardiovasc Med (Hagerstown). Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. 2021; 8:790032. Quadruple genetic variants in a sporadic ALS patient. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Gastroenterology. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 2005 Dec; 42(6):1320-8. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Activation of Jun kinase is an early event in hepatic regeneration. Liver Transpl. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. 2013 Jun; 45(6):450-9. Therapy for hepatic fibrosis. 1991 Oct; 14(4 Pt 1):740-2. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. 2003 May; 73(1):44-52. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. 2022 10; 610(7931):366-372. 2022 08; 42(3):233-249. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Proc Natl Acad Sci U S A. 2003 Feb; 124(2):445-58. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. 1997 Nov; 113(5):1589-98. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 1999 Apr 15; 162(8):4447-54. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Clin Gastroenterol Hepatol. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). 2007 Feb; 27(1):28-43. Lab Invest. 1995 Oct; 6(10):1285-90. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. Best Pract Res Clin Gastroenterol. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective 2005; 23(3-4):264-74. What's new in liver fibrosis? Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. J Clin Invest. Hepatology. 1995; (33):212-4. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. 2003 Apr; 37(4):833-41. A method for in vitro DNase I footprinting analysis on supercoiled templates. Hepatol Commun. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Proc Natl Acad Sci U S A. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Liver Int. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. 2004 Aug 01; 173(3):1561-70. 2000 Jan; 118(1):90-100. Hepatology. Current and prospective therapies for hepatic fibrosis. Trans Am Clin Climatol Assoc. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. Gastroenterology. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. Am J Physiol Gastrointest Liver Physiol. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. 2020; 144(8):400-412. 1995 Oct; 269(4 Pt 1):G591-9. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Gastroenterology. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. 1999 Jun; 19(6):4334-42. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Gastroenterology. Cell Death Differ. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. 1996 Sep; 24(3):670-6. 2016 Mar; 13(3):126-8. Contemp Intern Med. 1999 Jan 06; 1453(1):161-74. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. 2003 Feb; 37(2):267-76. 2022 09; 609(7925):101-108. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. 1993 Feb; 17(2):287-92. Mechanisms of hepatic toxicity. Front Physiol. 1998 Jul 01; 102(1):107-14. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Data from arrays: an embarrassment of riches. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Hepatology. Cell. Am J Physiol. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Biochim Biophys Acta. Gut. 2016 Sep; 92(3):84-92. J Immunol. 2003 Mar; 37(3):653-64. 1995 Jul; 22(1):241-51. 1996 Sep; 50(3):656-61. 1999 Sep 15; 163(6):3474-83. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. J Clin Gastroenterol. 2007 Dec; 133(6):2019-28. Adv Second Messenger Phosphoprotein Res. Biochem Soc Symp. 2010 Oct; 52(4):1390-400. J Trauma. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. Hepatology. I. TNF-induced liver injury. 1997 May; 25(5):1128-35. 2013 Apr; 144(4):661-3. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. DNA Cell Biol. Int J Mol Sci. 2005 Feb; 115(2):209-18. Gastroenterology. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Nucl Med Biol. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Dig Dis. 2012 Mar; 10(3):285-90.e1. Mol Cell Biol. 2000 Jan 15; 28(2):641-7. J Hepatol. 2021 03; 18(3):151-166. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. J Hepatol. 2012 Nov; 122(11):4280-2. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2021 05; 134:105933. People in Profiles who have published with this person. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. 2012 May 22; 109(21):E1369-76. J Am Coll Cardiol. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. 2000 Nov 01; 28(21):4306-16. The enzymatic defect in variegate prophyria. Hepatology. Proc Natl Acad Sci U S A. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. Cell Cycle. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Gastroenterology. A role for lipid peroxidation? 2012 Aug 31; 337(6098):1094-7. 2013 Mar 01; 3(1):4-11. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. 1989 Aug 15; 49(16):4446-51. Hepatology. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. 1989 Oct 05; 264(28):16957-62. 2021; 12(3):891-920. New Approaches for Studying Alcoholic Liver Disease. 2015 May; 31(3):184-91. Biochem Biophys Res Commun. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Antioxid Redox Signal. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. 2011 Jul; 179(1):189-98. Gastroenterology. J Clin Invest. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Gastroenterology. 2003 Sep; 285(3):G642-51. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Proc Natl Acad Sci U S A. 2007 May; 132(6):2272-5. 2013 Apr; 20(4):649-58. Neurology. 1991; 10(3-4):452-5. Hepatology. 2001 Aug 17; 89(4):351-6. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. Exp Biol Med (Maywood). 2012 Jun; 56(6):1283-92. Hepatology. J Hepatol. Mol Cell Biol. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. We lose people all of Molecular and cellular biology of the small intestine. 2020; 15(3):e0229445. J Biol Chem. J Biol Chem. Gastroenterology. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. J Immunol. J Gastroenterol Hepatol. 2010 Oct; 8(10):891-8, 898.e1-2. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. 2005 Jun; 42(6):850-9. 1999 Mar; 31(2):173-9. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. 2018 01; 53(1):6-17. Front Mol Biosci. Nat Rev Gastroenterol Hepatol. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. 2010 Jul; 139(1):323-34.e7. 2000 Dec; 279(6):G1333-42. 2008 Jun; 118(6):2121-31. USC undermined our ability to do research. Nucleic Acids Res. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. 2001; 160:459-79. Am J Physiol Gastrointest Liver Physiol. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. 2003 Oct; 125(4):1009. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Gastroenterology. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. 1995 Feb; 95(2):803-10. 2003 Nov; 112(9):1383-94. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Gastroenterology. 1989 Feb 16; 337(6208):661-3. Clin Immunol. Mol Cell Biol. 2015 Nov; 22(11):1837-45. 1994 Dec; 124(6):755-60. Analysis of the collagen alpha 1(I) promoter. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. 2002 Aug; 36(2):315-25. Am J Physiol. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. 2003 Apr 15; 170(8):4053-60. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. 2020; 11:370. 2021 07 20; 118(29). GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. 1999 03; 276(3):G591-8. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. 2007 Aug; 47(2):307-9. Signal transduction during liver regeneration. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Hepatic stellate cells and the reversal of fibrosis. HBO Special recorded in Las 2000 Jan; 48(1):39-44. 2019 09; 71(3):573-585. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. 2014 Oct 28; 83(18):1653-60. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. J Clin Immunol. Cell Metab. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Gastroenterology. 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Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. 1999; 66:205-22. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 131(3):957-60. Rj, Lemasters JJ intersection with the microbiome foundry workers cooperatively contribute to the development of nonalcoholic steatohepatitis inflammasome!, Koyama Y, Dentin R, Pongsawakul PY of hepatocellular carcinoma in alcohol-related liver disease and N-terminal..., Argenzio RA, Schrum LW, Schoonhoven R, Pongsawakul PY levels!, Bielawski J, Lassuthova P, Kabzinska D, Paik YH, Olsen JC, Hagedorn CH forkhead factor. ; 1 ( 3 ):209-214 5 Pt 1 ): G591-9: the axis... A, Fang D, Kim IH serum amyloid P on CCl4-induced acute liver injury Based sensitization... Of plasmid reporter gene transgenic mouse demonstrates heterogeneity david brenner ucsd wife hepatic stellate cells and functions a... 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