Li-Shu Wang, PhD

Li-Shu Wang, PhD.


Dr. Wang is a Research Scientist at the Medical College of Wisconsin and has worked previously at the Comprehensive Cancer Center at Ohio State University. She received her Ph.D. in Veterinary Biosciences in the College of Veterinary Medicine at Ohio State in June, 2006, and immediately joined Dr. Gary Stoner’s laboratory as a Post-doctoral researcher. She has experience in evaluating the effects of chemopreventive agents, including black raspberries, on gene expression in vitro (in mammary and colon cell culture systems) and in vivo (in the rat esophagus and in human colon). Using bio-directed fractionation, she showed that the anthocyanins in black raspberries are important for their chemopreventive effects and, recently, she provided evidence that the ellagitannins may be less important.

Using DNA microarray, Dr. Wang investigated the effects of a black raspberry diet on gene expression during the early and late stages of rat esophageal carcinogenesis and has shown that the berries exhibit a genome-wide effect on the expression of genes associated with multiple cellular processes including proliferation, apoptosis, inflammation, angiogenesis, cell cycling and cell adhesion, carbohydrate metabolism and cell differentiation. Recently, she has evidence that berries cause demethylation of tumor suppressor genes in rodent and human colon leading to their enhanced expression. Currently, she has 30 peer-reviewed publications including two manuscripts in press.