Tong Chen, MD, PhD

Tong Chen, MD, PhD

Tong Chen, M.D., Ph.D., is an Assistant Professor in Division of Medical Oncology, Department of Internal Medicine at The Ohio State University (OSU). She is also a member of the Molecular Carcinogenesis and Chemoprevention Program in OSU Comprehensive Cancer Center. Dr. Chen received her Ph.D. from OSU in 2003. She has more than 15 years of experience in the area of medicine, molecular carcinogenesis and cancer chemoprevention.

Dr. Chen’s current research focuses on molecular carcinogenesis and cancer chemoprevention of
esophageal squamous cell carcinoma (SCC) by the use of a carcinogen-rat model. This animal
model mimics the neoplastic process occurring in humans and has proven to be an extremely
valuable animal model for studying the molecular mechanisms involved in esophageal SCC.

Esophageal SCC is one of the most common malignant neoplasms worldwide, and its incidence is disproportionately high in African Americans. Recently, Dr. Chen and her team conducted an international collaborative Phase II clinical trial in the region of China that has the highest incidence of esophageal SCC. They found that dietary intake of strawberries (60 g/day for 6 months) inhibited the progression of precancerous growth in patients who had been diagnosed with esophageal dysplasia. They now plan to confirm and extend these findings by conducting a randomized placebo-controlled trial with berries.

Dr. Chen serves as the PI on several research grants including a NCI RO1 grant, an international collaborative research grant funded by NIH and the National Natural Science Foundation of China, and some others.